Recipe Details

HIV Recipe and Ingredient Parameters and Resources:

Note: Many proteins will be found in both compartments including excess copies of the nuclear Capsid protein as well as RT and IN bound to the RNA.

Information on genes and gene products from http://www.hiv.lanl.gov/content/sequence/HIV/MAP/landmark.html:

gag– called "assemblin", the gag precursor p55 myristoylated protein is processed into p17 (MAtrix), p7 (NucleoCapsid), and p6 protein by viral protease.

pol– encodes the viral enzymes protease, reverse transcriptase, and integrate produces as a gag-pol precursor polyprotein which is then processed by the viral protease

env

PDB list from http://www.hiv.lanl.gov/content/sequence/PROTVIS/html/protvis.html

http://www.callutheran.edu/BioDev/omm/exhibits.htm

HIV toolbox for gene product information: http://hivtoolbox.bio-toolkit.com/HIVToolbox/Index

A beautiful and useful visual reference:

http://visualscience.ru/en/projects/hiv/illustrations/

HIV-protease self-cleavage mechanism: http://www.pnas.org/content/early/2012/11/21/1210983109.full.pdf including this image of GagPol: http://www.pnas.org/content/109/50/20449/F1.expansion.html